pH sensitive functionalized hyperbranched polyester based nanoparticulate system for the receptor-mediated targeted cancer therapy

Ozturk A. B., Cevher E., Pabuccuoglu S., Ozgumus S.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, cilt.68, sa.8, ss.417-432, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 8
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/00914037.2018.1452226
  • Dergi Adı: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.417-432
  • Anahtar Kelimeler: 5-fluorouracil, cancer therapy, hyperbranched polyester, pH sensitive nanoparticles, receptor-mediated targeting, targeted drug carrier, CELLULAR UPTAKE, DRUG-DELIVERY, IN-VITRO, SUPERPARAMAGNETIC NANOPARTICLES, SURFACE MODIFICATION, PARTICLE-SIZE, RELEASE, CELLS, 5-FLUOROURACIL, DOXORUBICIN
  • İstanbul Üniversitesi Adresli: Evet

Özet

The aim of this study is to develop a novel folic acid conjugated, DL-lysine modified, PEGylated, the 3rd generation hyperbranched polymer (HBP-PEG-Lys-FA) for use in receptor-mediated therapy. 5-fluorouracil, model anti-cancer drug, loaded nanoparticles were found an average size of 177 nm with loading efficiency of 23.18%. In vitro drug release studies demonstrated that nanoparticles showed pH-dependent release. HBP-PEG-Lys-FA were efficiently taken up by HeLa cells and specificity of targeted nanoparticles to folate receptors of cells was proved. It was concluded that the HBP-PEG-Lys-FA nanoparticles can provide an advantage on delivering of the drug efficiently into the cytosol for cancer therapy.