Attenuation of ischemia/reperfusion injury by N-acetylcysteine in a rat hind limb model

Koksal C., Bozkurt A., Cangel U., Ustundag N., Konukoglu D., Musellim B., ...More

JOURNAL OF SURGICAL RESEARCH, vol.111, no.2, pp.236-239, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 111 Issue: 2
  • Publication Date: 2003
  • Doi Number: 10.1016/s0022-4804(03)00094-5
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.236-239
  • Istanbul University Affiliated: Yes


Background. Ischemia/reperfusion is a complex set of events with severe pathologic consequences. Reperfusion initiates both the local and systemic damage in part through rapid oxygen generation. N-acetylcysteine (NAC) is a scavenger of free radical species, inhibits neutrophil accumulation, acts as a vasodilator and also improves microcirculation. In present study, we examined the protective effect of NAC in a rat hind limb ischemia/reperfusion model. Dimethyl-sulfoxide (DMSO), a well-known antioxidant was also tested for comparison.