Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome

Disanto, Giulio; Adiutori, Rocco; Dobson, Ruth; Martinelli, Vittorio; Costa, Gloria; Runia, Tessel; Evdoshenko, Evgeniy; Thouvenot, Eric; Trojano, Maria; Norgren, Niklas; Teunissen, Charlotte; Kappos, Ludwig; Giovannoni, Gavin; Kuhle, Jens; Bianchi, Lucia; Topping, Joanne; Bestwick, Jonathan; Meier, Ute-Christiane; Lazareva, Natalia; Iaffaldano, Pietro; Direnzo, Vita; Khademi, Mohsen; Piehl, Fredrik; Comabella, Manuel; Sombekke, Madeleine; Killestein, Joep; Hegen, Harald; Rauch, Stefan; D'Alfonso, Sandra; Alvarez-Cermeno, Jose; Kleinova, Pavlina; Horakova, Dana; Roesler, Romy; Lauda, Florian; Llufriu, Sara; Avsar, Timucin; Uygunoglu, Uğur; Altintas, Ayşe; Saip, Sabahattin; Menge, Til; Rajda, Cecilia; Bergamaschi, Roberto; Moll, Natalia; Khalil, Michael; Marignier, Romain; Dujmovic, Irena; Larsson, Henrik; Malmestrom, Clas; Scarpini, Elio; Fenoglio, Chiara; Wergeland, Stig; Laroni, Alice; Annibali, Viviana; Romano, Silvia; Martinez, Alejandra; Carra, Adriana; Salvetti, Marco; Uccelli, Antonio; Torkildsen, Oivind; Myhr, KjellMorten; Galimberti, Daniela; Rejdak, Konrad; Lycke, Jan; Frederiksen, Jette; Drulovic, Jelena; Confavreux, Christian; Brassat, David; Enzinger, Christian; Fuchs, Siegrid; Bosca, Isabel; Pelletier, Jean; Picard, Christophe; Colombo, Elena; Franciotta, Diego; Derfuss, Tobias; Lindberg, Raija; Yaldizli, Ozgur; Vecsei, Laszlo; Kieseier, Bernd; Hartung, Hans; Villoslada, Pablo; Siva, Aksel; Saiz, Albert; Tumani, Hayrettin; Havrdova, Eva; Villar, Luisa; Leone, Maurizio; Barizzone, Nadia; Deisenhammer, Florian; Montalban, Xavier; Tintore, Mar; Olsson, Tomas; Lehmann, Sylvain; Castelnovo, Giovanni; Lapin, Sergey; Hintzen, Rogier; Furlan, Roberto; Comi, Giancarlo; Ramagopalan, Sreeram

doi:10.1136/jnnp-2014-309690

Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome

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Disanto G., Adiutori R., Dobson R., Martinelli V., Costa G. D., Runia T., ...More

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, vol.87, no.2, pp.126-129, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 87 Issue: 2
Publication Date: 2016
Doi Number: 10.1136/jnnp-2014-309690
Journal Name: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.126-129
Istanbul University Affiliated: Yes

Abstract

Background Neurofilament light chain (NfL) represents a promising biomarker for axonal injury. We present the first exploratory study on serum NfL in patients with a clinically isolated syndrome (CIS) and healthy controls.