Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium

Peyrot, Wouter; Van der Auwera, Sandra; Milaneschi, Yuri; Dolan, Conor; Madden, Pamela; Sullivan, Patrick; Strohmaier, Jana; Ripke, Stephan; Rietschel, Marcella; Nivard, Michel; Mullins, Niamh; Montgomery, Grant; Henders, Anjali; Heat, Andrew; Fisher, Helen; Dunn, Erin; Byrne, Enda; Air, Tracy; Depressive, Major; Baune, Bernhard; Breen, Gerome; Levinson, Douglas; Lewis, Cathryn; Martin, Nick; Nelson, Elliot; Boomsma, Dorret; Grabe, Hans; Wray, Naomi; Penninx, Brenda

doi:10.1016/j.biopsych.2017.09.009

Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium

Peyrot W. J., Van der Auwera S., Milaneschi Y., Dolan C. V., Madden P. A. F., Sullivan P. F., ...More

BIOLOGICAL PSYCHIATRY, vol.84, no.2, pp.138-147, 2018 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 84 Issue: 2
Publication Date: 2018
Doi Number: 10.1016/j.biopsych.2017.09.009
Journal Name: BIOLOGICAL PSYCHIATRY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.138-147
Keywords: Childhood trauma, Depression, Genetics, Interaction, Meta-analysis, Polygenic risk, GENE-ENVIRONMENT INTERACTION, MAJOR DEPRESSION, LIFE STRESS, 5-HTTLPR, VARIANTS, ASSOCIATION, DISORDERS, LOCI, PSYCHOPATHOLOGY, QUESTIONNAIRE
Istanbul University Affiliated: No

Abstract

BACKGROUND: The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. This study aims to meta-analyze MDD-PRS 3 CT interaction results across these two and other cohorts, while applying more accurate PRSs based on a larger discovery sample.