Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium

Peyrot W. J., Van der Auwera S., Milaneschi Y., Dolan C. V., Madden P. A. F., Sullivan P. F., ...Daha Fazla

BIOLOGICAL PSYCHIATRY, cilt.84, sa.2, ss.138-147, 2018 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 84 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.biopsych.2017.09.009
  • Dergi Adı: BIOLOGICAL PSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.138-147
  • Anahtar Kelimeler: Childhood trauma, Depression, Genetics, Interaction, Meta-analysis, Polygenic risk, GENE-ENVIRONMENT INTERACTION, MAJOR DEPRESSION, LIFE STRESS, 5-HTTLPR, VARIANTS, ASSOCIATION, DISORDERS, LOCI, PSYCHOPATHOLOGY, QUESTIONNAIRE
  • İstanbul Üniversitesi Adresli: Hayır

Özet

BACKGROUND: The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. This study aims to meta-analyze MDD-PRS 3 CT interaction results across these two and other cohorts, while applying more accurate PRSs based on a larger discovery sample.