Clinical and Laboratory Factors Affecting the Prognosis of Severe Combined Immunodeficiency

ÖZTÜRK, ELİF; Catak, Mehmet; KIYKIM, AYÇA; Baser, Dilek; Bilgic Eltan, Sevgi; Yalcin, Koray; Kasap, Nurhan; Nain, Ercan; Bulutoglu, Alper; Akgun, Gamze; Can, Yasemin; Sefer, Asena; Babayeva, Royala; Caki-Kilic, Suar; Tezcan Karasu, Gulsun; Yesilipek, Akif; Ozen, Ahmet; Karakoc-Aydiner, Elif; BARIŞ, SAFA

doi:10.1007/s10875-022-01262-0

Clinical and Laboratory Factors Affecting the Prognosis of Severe Combined Immunodeficiency

ÖZTÜRK E., Catak M. C., KIYKIM A., Baser D., Bilgic Eltan S., Yalcin K., ...Daha Fazla

JOURNAL OF CLINICAL IMMUNOLOGY, cilt.42, sa.5, ss.1036-1050, 2022 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 42 Sayı: 5
Basım Tarihi: 2022
Doi Numarası: 10.1007/s10875-022-01262-0
Dergi Adı: JOURNAL OF CLINICAL IMMUNOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
Sayfa Sayıları: ss.1036-1050
Anahtar Kelimeler: Severe combined immunodeficiency, Bone marrow transplantation, Immune reconstitution, T-cell receptor repertoire, Prognosis, STEM-CELL TRANSPLANTATION, IMMUNE RECONSTITUTION, BONE-MARROW, CHILDREN, SURVIVAL, OUTCOMES
İstanbul Üniversitesi Adresli: Evet

Özet

Purpose Severe combined immunodeficiency (SCID) is one of the most severe forms of inborn errors of immunity characterized by absence or loss of function in T cells. The long-term outcomes of all forms of SCID have been evaluated in a limited number of studies. We aimed to evaluate the pre- and post-transplant manifestations of SCID patients and determine the factors affecting the survival of patients.