Effects of fluoxetine, tianeptine and olanzapine on unpredictable chronic mild stress-induced depression-like behavior in mice

MUTLU O., Gumuslu E., ULAK G., Celikyurt I. K., Kokturk S., Kir H. M., ...Daha Fazla

LIFE SCIENCES, cilt.91, ss.1252-1262, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 91
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.lfs.2012.09.023
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1252-1262
  • Anahtar Kelimeler: Depression, Unpredictable chronic mild stress, Tianeptine, Olanzapine, Fluoxetine, Mice, ANTIDEPRESSANT-LIKE ACTION, TAIL SUSPENSION TEST, LONG-TERM, HIPPOCAMPAL NEUROGENESIS, INDUCED ANHEDONIA, PREDATOR STRESS, SPATIAL MEMORY, NOS INHIBITOR, MODEL, INVOLVEMENT
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Aims: Tianeptine is an atypical antidepressant drug that has a different mechanism of action than other antidepressants. Olanzapine is an atypical antipsychotic drug used for the treatment of schizophrenia. The present study was undertaken to investigate effects of chronic administration of tianeptine or olanzapine on unpredictable chronic mild stress (UCMS)-induced depression-like behavior in mice compared to a widely used SSRI antidepressant, fluoxetine.