Effects of fluoxetine, tianeptine and olanzapine on unpredictable chronic mild stress-induced depression-like behavior in mice


MUTLU O., Gumuslu E., ULAK G., Celikyurt I. K. , Kokturk S. , Kir H. M. , ...Daha Fazla

LIFE SCIENCES, cilt.91, ss.1252-1262, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 91
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.lfs.2012.09.023
  • Dergi Adı: LIFE SCIENCES
  • Sayfa Sayıları: ss.1252-1262

Özet

Aims: Tianeptine is an atypical antidepressant drug that has a different mechanism of action than other antidepressants. Olanzapine is an atypical antipsychotic drug used for the treatment of schizophrenia. The present study was undertaken to investigate effects of chronic administration of tianeptine or olanzapine on unpredictable chronic mild stress (UCMS)-induced depression-like behavior in mice compared to a widely used SSRI antidepressant, fluoxetine.