Effects of fluoxetine, tianeptine and olanzapine on unpredictable chronic mild stress-induced depression-like behavior in mice

MUTLU O., Gumuslu E., ULAK G., Celikyurt I. K., Kokturk S., Kir H. M., ...More

LIFE SCIENCES, vol.91, pp.1252-1262, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 91
  • Publication Date: 2012
  • Doi Number: 10.1016/j.lfs.2012.09.023
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1252-1262
  • Keywords: Depression, Unpredictable chronic mild stress, Tianeptine, Olanzapine, Fluoxetine, Mice, ANTIDEPRESSANT-LIKE ACTION, TAIL SUSPENSION TEST, LONG-TERM, HIPPOCAMPAL NEUROGENESIS, INDUCED ANHEDONIA, PREDATOR STRESS, SPATIAL MEMORY, NOS INHIBITOR, MODEL, INVOLVEMENT
  • Istanbul University Affiliated: No

Abstract

Aims: Tianeptine is an atypical antidepressant drug that has a different mechanism of action than other antidepressants. Olanzapine is an atypical antipsychotic drug used for the treatment of schizophrenia. The present study was undertaken to investigate effects of chronic administration of tianeptine or olanzapine on unpredictable chronic mild stress (UCMS)-induced depression-like behavior in mice compared to a widely used SSRI antidepressant, fluoxetine.