This clinical report describes the prosthodontic rehabilitation of an edentulous patient with a maxillary defect using the biofunctional prosthetic system. The Biofunctional Prosthetic System brand denture includes a comprehensive technique for impressions, record taking, tooth placement, fabrication and processing. The advantage of this technique is to provide patients with optimal form, function, and aesthetics in complete dentures. This system is based on a team effort and systematic approach to removable prosthetic treatment. © 2005 Blackwell Publishing Ltd.