Can ebselen prevent cisplatin-induced ovarian damage?

SOYMAN, Zeynep; Uzun, Hafize; Bayindir, Nihan; EŞREFOĞLU, MUKADDES; BORAN, Birtan

doi:10.1007/s00404-018-4750-4

Can ebselen prevent cisplatin-induced ovarian damage?

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SOYMAN Z., Uzun H., Bayindir N., EŞREFOĞLU M., BORAN B.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, vol.297, no.6, pp.1549-1555, 2018 (SCI-Expanded)

Publication Type: Article / Article
Volume: 297 Issue: 6
Publication Date: 2018
Doi Number: 10.1007/s00404-018-4750-4
Journal Name: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1549-1555
Istanbul University Affiliated: Yes

Abstract

Purpose The occurrence of ovarian damage is a major shortcoming in treating tumors with cisplatin (CP). The present study investigates the beneficial effects of ebselen-a seleno-organic compound with antioxidant and antiinflammatory properties-vis-a-vis CP-induced ovarian damage.