Potential effects of L-NAME on alcohol-induced oxidative stress

Uzun H., Simsek G., Aydin S., Unal E., Karter Y., Yelmen N. K., ...More

WORLD JOURNAL OF GASTROENTEROLOGY, vol.11, no.4, pp.600-604, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 4
  • Publication Date: 2005
  • Doi Number: 10.3748/wjg.v11.i4.600
  • Journal Name: WORLD JOURNAL OF GASTROENTEROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.600-604
  • Istanbul University Affiliated: Yes

Abstract

AIM: Nitric oxide (NO) is a highly reactive oxidant synthesized from L-arginine by nitric oxide synthase (NOS). NO may cause injury through the generation of potent radicals. Nw-nitro-L-arginine methyl ester (L-NAME) is a non-selective inhibitor of NOS. We aimed to evaluate whether L-NAME treatment had protective effects against oxidative stress in rats intragastrically fed with ethanol during a 4 wk-period.