Tubular markers in children with insulin-dependent diabetes mellitus.

Caliskan S., FICICIOGLU C., HACIBEKIROGLU M., MIKLA S., KASAPCOPUR O., SEVER L., ...More

TURKISH JOURNAL OF PEDIATRICS, vol.39, no.2, pp.213-218, 1997 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 2
  • Publication Date: 1997
  • Journal Name: TURKISH JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.213-218
  • Istanbul University Affiliated: Yes

Abstract

The aim of the present study was to Investigate the prevalence of tubular dysfunction and to assess the clinical significance of low-molecular-weight proteinuria and enzymuria. In children with insulin-dependent diabetes mellitus (IDDM). N.acetyl-beta-D-glucosaminidase (NAG) and beta-microglobulin (beta(2)M) excretion was determined in 52 children with insulin-dependent diabetes mellitus and 28 controls. Patients were grouped according to the duration of diabetes: group 1 (n = 7): less than one year; group 2 (n = 27): one to five years; groups 3 (n = 18): greater than five years. Both parameters were significantly Increased in groups 2 and 3 compared to controls. Urinary B2M levels correlated significantly with albuminuria and HbA(1C), while urinary NAG levels correlated only with HbA(1C).