Identification of PIK3CA aberrations associated with telomere length in breast cancer

Dirican E., Velidedeoglu M., Ilvan S., Ozturk T., Altintas T., Ayni E. B., ...Daha Fazla

GENE REPORTS, cilt.19, 2020 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.genrep.2020.100597
  • Dergi Adı: GENE REPORTS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, BIOSIS, EMBASE
  • İstanbul Üniversitesi Adresli: Evet

Özet

PIK3CA (p110 alpha) mutations are the most common alterations in the phosphoinositide 3-kinase (PI3K) pathway, affecting about 27% of breast cancer (BCa) patients. Telomeres play crucial roles in chromosomal maintenance and stability. This study investigated the correlations between telomere length and PIK3CA mutations in BCa patients and compared these findings with the patients' clinical parameters.