Identification of PIK3CA aberrations associated with telomere length in breast cancer


Dirican E., Velidedeoglu M. , Ilvan S. , Ozturk T., Altintas T., Ayni E. B. , ...More

GENE REPORTS, vol.19, 2020 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19
  • Publication Date: 2020
  • Doi Number: 10.1016/j.genrep.2020.100597
  • Title of Journal : GENE REPORTS

Abstract

PIK3CA (p110 alpha) mutations are the most common alterations in the phosphoinositide 3-kinase (PI3K) pathway, affecting about 27% of breast cancer (BCa) patients. Telomeres play crucial roles in chromosomal maintenance and stability. This study investigated the correlations between telomere length and PIK3CA mutations in BCa patients and compared these findings with the patients' clinical parameters.