Identification of PIK3CA aberrations associated with telomere length in breast cancer

Dirican E., Velidedeoglu M., Ilvan S., Ozturk T., Altintas T., Ayni E. B., ...More

GENE REPORTS, vol.19, 2020 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19
  • Publication Date: 2020
  • Doi Number: 10.1016/j.genrep.2020.100597
  • Journal Name: GENE REPORTS
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, BIOSIS, EMBASE
  • Istanbul University Affiliated: Yes


PIK3CA (p110 alpha) mutations are the most common alterations in the phosphoinositide 3-kinase (PI3K) pathway, affecting about 27% of breast cancer (BCa) patients. Telomeres play crucial roles in chromosomal maintenance and stability. This study investigated the correlations between telomere length and PIK3CA mutations in BCa patients and compared these findings with the patients' clinical parameters.