Late Versus Early Myocardial Remodeling After Acute Myocardial Infarction: A Comparative Review on Mechanistic Insights and Clinical Implications

Yalta K., YILMAZ M. B., Yalta T., PALABIYIK O., TAYLAN G., ZORKUN C. S.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, cilt.25, sa.1, ss.15-26, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 25 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1177/1074248419869618
  • Dergi Adı: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.15-26
  • Anahtar Kelimeler: acute myocardial infarction, late myocardial remodeling, early myocardial remodeling, systemic inflammation, growth factors, clinical implications, ARGININE-VASOPRESSIN INCREASES, HEART-FAILURE, CARDIOVASCULAR-DISEASE, INFLAMMATORY RESPONSE, RHEUMATOID-ARTHRITIS, MONOCLONAL-ANTIBODY, ST2, THERAPY, REPAIR, DYSFUNCTION
  • İstanbul Üniversitesi Adresli: Evet

Özet

In the setting of acute myocardial infarction (AMI), adverse myocardial remodeling (AMR) has been universally regarded as an early-onset phenomenon generally arising within the first few weeks (usually within days in the infarct zone) following myocardial injury. On the other hand, onset of cardiac morphological changes in this setting may potentially extend far beyond this time frame (usually beyond several months after the index AMI), suggesting a prolonged latent period in certain cases. In clinical practice, this delayed form of post-AMI remodeling, namely late AMR, has emerged as an interesting and underrecognized phenomenon with poorly understood mechanisms. Notably, systemic inflammation and associated growth factors seem to play a pivotal role in this setting. Accordingly, the present article primarily aims to discuss potential mechanisms and clinical implications of late AMR (in a comparative manner with its classical early counterpart) among AMI survivors along with a particular emphasis on potential benefits of certain anti-inflammatory strategies in this setting.