Oxidative DNA Damage and Antioxidant Defense After Reperfusion in Acute Myocardial Infarction

Himmetoglu S., Dincer Y., Bozcali E., Vural V. A., Akcay T.

JOURNAL OF INVESTIGATIVE MEDICINE, cilt.57, sa.4, ss.595-599, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 4
  • Basım Tarihi: 2009
  • Doi Numarası: 10.2310/jim.0b013e31819d87c1
  • Dergi Adı: JOURNAL OF INVESTIGATIVE MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.595-599
  • İstanbul Üniversitesi Adresli: Evet

Özet

Purpose: Myocardial damage mediated by oxidative stress during acute myocardial infarction (MI) has been suggested as an obstructive factor on recovery after an MI. 8-Hydroxydeoxyguanosine (8-OHdG) is a marker for oxidative DNA damage; superoxide dismutase (SOD) and glutathione peroxidase (G-Px) are major antioxidant enzymes. We determined changes in the plasma level of 8-OHdG and activities of SOD and G-Px in patients with MI and examined the relations between those changes and other cardiac markers.