Oxidative DNA Damage and Antioxidant Defense After Reperfusion in Acute Myocardial Infarction


Himmetoglu S., Dincer Y. , Bozcali E., Vural V. A. , Akcay T.

JOURNAL OF INVESTIGATIVE MEDICINE, vol.57, no.4, pp.595-599, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 4
  • Publication Date: 2009
  • Doi Number: 10.2310/jim.0b013e31819d87c1
  • Title of Journal : JOURNAL OF INVESTIGATIVE MEDICINE
  • Page Numbers: pp.595-599

Abstract

Purpose: Myocardial damage mediated by oxidative stress during acute myocardial infarction (MI) has been suggested as an obstructive factor on recovery after an MI. 8-Hydroxydeoxyguanosine (8-OHdG) is a marker for oxidative DNA damage; superoxide dismutase (SOD) and glutathione peroxidase (G-Px) are major antioxidant enzymes. We determined changes in the plasma level of 8-OHdG and activities of SOD and G-Px in patients with MI and examined the relations between those changes and other cardiac markers.