Oxidative DNA Damage and Antioxidant Defense After Reperfusion in Acute Myocardial Infarction
JOURNAL OF INVESTIGATIVE MEDICINE, vol.57, no.4, pp.595-599, 2009 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 57 Issue: 4
- Publication Date: 2009
- Doi Number: 10.2310/jim.0b013e31819d87c1
- Journal Name: JOURNAL OF INVESTIGATIVE MEDICINE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.595-599
- Istanbul University Affiliated: Yes
Abstract
Purpose: Myocardial damage mediated by oxidative stress during acute myocardial infarction (MI) has been suggested as an obstructive factor on recovery after an MI. 8-Hydroxydeoxyguanosine (8-OHdG) is a marker for oxidative DNA damage; superoxide dismutase (SOD) and glutathione peroxidase (G-Px) are major antioxidant enzymes. We determined changes in the plasma level of 8-OHdG and activities of SOD and G-Px in patients with MI and examined the relations between those changes and other cardiac markers.