Melatonin Expresses Powerful Anti-inflammatory and Antioxidant Activities Resulting in Complete Improvement of Acetic-Acid-Induced Colitis in Rats

Tahan G., Gramignoli R., Marongiu F., Aktolga S., Cetinkaya A., Tahan V., ...More

DIGESTIVE DISEASES AND SCIENCES, vol.56, no.3, pp.715-720, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.1007/s10620-010-1364-5
  • Journal Name: DIGESTIVE DISEASES AND SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.715-720
  • Istanbul University Affiliated: Yes

Abstract

Increased free-radical production, decreased antioxidant capacity, and excessive inflammation are well-known features in the pathogenesis of inflammatory bowel disease. Melatonin is a powerful antioxidant and a scavenger of hydroxyl radicals. Melatonin has also been shown to have anti-inflammatory activities in tissues. Our study objective is to investigate the effects of melatonin on tissue inflammatory activities using an ulcerative colitis (UC) model induced by acetic acid (AA) in rats.