Determinants of glucose metabolism and the role of NPY in the progression of insulin resistance in chronic migraine

Siva Z. O. , Uluduz D. , Keskin F. E. , Erenler F., Balci H. , Uygunoglu U. , ...Daha Fazla

CEPHALALGIA, cilt.38, ss.1773-1781, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 38 Konu: 11
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1177/0333102417748928
  • Dergi Adı: CEPHALALGIA
  • Sayfa Sayıları: ss.1773-1781


Background Chronic migraine has a well-documented association with increased insulin resistance and metabolic syndrome. The hypothalamus may play a role in the progression of insulin resistance in chronic migraine through the regulation of orexigenic peptides such as neuropeptide Y. Insulin resistance may lead to increased risk of future type 2 diabetes mellitus in patients with chronic migraine, which is more likely to occur if other pathogenetic defects of type 2 diabetes mellitus, such as impaired pancreatic -cell functions and defects in intestinal glucagon-like peptide-1 secretion after meals. We studied the relationship of fasting neuropeptide Y with insulin resistance, -cell function, and glucagon-like peptide-1 secretion in non-obese female chronic migraine patients. We also aimed to investigate glucose-stimulated insulin and glucagon-like peptide-1 secretions as early pathogenetic mechanisms responsible for the development of carbohydrate intolerance.