Association of the CC chemokine receptor 5 (CCR5) polymorphisms with preeclampsia in Turkish women

Gurdol F., Yurdum L. M., Ozturk U., Isbilen E., Cakmakoglu B.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, cilt.286, sa.1, ss.51-54, 2012 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 286 Sayı: 1
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s00404-012-2244-3
  • Dergi Adı: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.51-54
  • Anahtar Kelimeler: Chemokines, Polymorphism, Preeclampsia, Receptor, PROMOTER POLYMORPHISM, EXPRESSION, GENE, RESISTANCE, CYTOKINES, RISK, PREGNANCY, DNA
  • İstanbul Üniversitesi Adresli: Evet

Özet

Endothelial dysfunction and inflammation are involved in the pathogenesis of preeclampsia. The CC chemokine receptor 5 (CCR5) modulates inflammation secondary to endothelial dysfunction and related vascular disorders, by initiating chemotaxis. In this study, we examined the frequency of two polymorphisms, the CCR5 Delta 32 deletion and the CCR5-59029 A/G promoter point mutation in women with preeclampsia.