Antiglycation and anti-oxidant efficiency of carnosine in the plasma and liver of aged rats.

Binguel İ., Yilmaz Z., Aydin A. F., Coban J., Dogru-Abbasoglu S., Uysal M.

Geriatrics & gerontology international, vol.17, no.12, pp.2610-2614, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 12
  • Publication Date: 2017
  • Doi Number: 10.1111/ggi.13126
  • Journal Name: Geriatrics & gerontology international
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.2610-2614
  • Keywords: advanced glycation end-products, aged rats, carnosine, liver, oxidative stress, GLYCATION END-PRODUCTS, OXIDATIVE STRESS, ASSAY, PROTEINS, TISSUES, DAMAGE, ACCUMULATION, DISEASE, BRAIN, HEART
  • Istanbul University Affiliated: Yes

Abstract

AimIncreases in oxidative stress and advanced glycation end-products (AGE) formation play an important role in the pathogenesis of aging. Carnosine (CAR; -alanyl-L-histidine) has anti-oxidant and antiglycating properties. We investigated the effect of CAR supplementation on AGE levels, and protein and lipid oxidation products in the serum and liver tissue in aged rats.