SYNTHESIS AND ANTIMICROBIALLY ACTIVITIES OF COUMARIN-3-CARBOXAMIDE DERIVATIVES

ÇELİK ONAR H., Bayramoğlu G., MATARACI KARA E.

Revue Roumaine de Chimie, vol.68, no.1-2, pp.85-89, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 1-2
  • Publication Date: 2023
  • Doi Number: 10.33224/rrch.2023.68.1-2.08
  • Journal Name: Revue Roumaine de Chimie
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.85-89
  • Istanbul University Affiliated: Yes

Abstract

In this study nine coumarin-3-carboxamide derivatives 3a-3i were synthesized with coumarin-3-carboxylic acid chloride and different amines. Two of them, 3c and 3i, are original. The novel substances were purified by column chromatography, and their structures were identified by spectroscopic methods (1H NMR,13C NMR, IR) and elemental analysis. Coumarin-3-carboxamide derivatives were evaluated antimicrobially against ten different ATTC isolates. The compound 3f was found to be the most effective compound in terms of antibacterial and antifungal activities.