Nanodelivery Approaches of Phytoactives for Skin Cancers: Current and Future Perspectives

Yapar E. A., Özdemir M. N., Durgun M. E., Dağıstan Ö., Cavalu S., Özsoy Y., ...More

CURRENT PHARMACEUTICAL BIOTECHNOLOGY, vol.26, no.5, pp.631-653, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 26 Issue: 5
  • Publication Date: 2025
  • Doi Number: 10.2174/0113892010300081240329033208
  • Journal Name: CURRENT PHARMACEUTICAL BIOTECHNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.631-653
  • Istanbul University Affiliated: Yes

Abstract

In recent years, there has been an increase in skin cancers due to external factors, especially environmental factors, and studies on treatment alternatives have gained importance. Nanomaterials are common, from sunscreen formulas to formulations designed to treat skin cancers at various stages. Using bioactives has multiple effects in treating skin cancers, which provides many advantages. In this regard, many phytochemicals gain importance with their antioxidant, anti-proliferative, anti-inflammatory, antiangiogenic, and analgesic effects. Their delivery with nanocarriers is on the agenda for phytochemicals to gain the targeted stability, effectiveness, and toxicity/safety properties. This review presents types of skin cancers, phytochemicals effective in skin cancers, and their nanocarrier-loaded studies from an up-to-date perspective.