A Malignant Transformation of a Spinal Epidural Mass from Ganglioneuroblastoma to Neuroblastoma


Akcakaya M. O. , Bilgic B., Aras Y., Izgi N.

JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, vol.57, no.3, pp.211-214, 2015 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.3340/jkns.2015.57.3.211
  • Journal Name: JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.211-214
  • Keywords: Ganglioneuroblastoma, Neuroblastoma, Malignant transformation, Spinal tumor, NERVE SHEATH TUMOR, NEURO-BLASTOMA, CORD COMPRESSION, RETROPERITONEAL GANGLIONEUROMA, DUMBBELL GANGLIONEUROMAS, ADULT, EXTENSION, CHILDREN, SURVIVAL, DISEASE

Abstract

Ganglioneuromas are benign tumors. Surgical excision is the treatment of choice with very good prognosis. However, neuroblastomatous malignant transformation of ganglioneuromas was previously reported. We report a patient with spinal neuroblastoma recurrent from a ganglioneuroblastoma after disease free survival of 13 years. This is one of the rare examples of spinal neuroblastoma and to our knowledge the second case report with malignant transformation from a ganglioneuroblastoma or a ganglioneuroma. The present case is the only report in the literature with further genetic investigations.