A Malignant Transformation of a Spinal Epidural Mass from Ganglioneuroblastoma to Neuroblastoma


Akcakaya M. O., Bilgic B., Aras Y., Izgi N.

JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, vol.57, no.3, pp.211-214, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.3340/jkns.2015.57.3.211
  • Journal Name: JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.211-214
  • Keywords: Ganglioneuroblastoma, Neuroblastoma, Malignant transformation, Spinal tumor, NERVE SHEATH TUMOR, NEURO-BLASTOMA, CORD COMPRESSION, RETROPERITONEAL GANGLIONEUROMA, DUMBBELL GANGLIONEUROMAS, ADULT, EXTENSION, CHILDREN, SURVIVAL, DISEASE
  • Istanbul University Affiliated: Yes

Abstract

Ganglioneuromas are benign tumors. Surgical excision is the treatment of choice with very good prognosis. However, neuroblastomatous malignant transformation of ganglioneuromas was previously reported. We report a patient with spinal neuroblastoma recurrent from a ganglioneuroblastoma after disease free survival of 13 years. This is one of the rare examples of spinal neuroblastoma and to our knowledge the second case report with malignant transformation from a ganglioneuroblastoma or a ganglioneuroma. The present case is the only report in the literature with further genetic investigations.