MOLECULAR GENETICS & GENOMIC MEDICINE, vol.8, no.8, 2020 (SCI-Expanded)
Article / Article
MOLECULAR GENETICS & GENOMIC MEDICINE
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, EMBASE, MEDLINE, Directory of Open Access Journals
amelogenesis imperfecta, dentin defects, enamel hardness, hypomineralization, MMP20 mutations
Istanbul University Affiliated:
Background Matrix metallopeptidase 20 (MMP20) is an evolutionarily conserved protease that is essential for processing enamel matrix proteins during dental enamel formation. MMP20 mutations cause human autosomal recessive pigmented hypomaturation-type amelogenesis imperfecta (AI2A2; OMIM #612529). MMP20 is expressed in both odontoblasts and ameloblasts, but its function during dentinogenesis is unclear.