Adipose Tissue Gene Expression of Adiponectin, Tumor Necrosis Factor-alpha and Leptin in Metabolic Syndrome Patients with Coronary Artery Disease

GORMEZ, Selcuk; DEMIRKAN, Ayse; Atalar, Fatmahan; Caynak, Baris; ERDIM, Refik; SÖZER, Volkan; GUNAY, Demet; Akpinar, Bellhan; Ozbek, Ugur; Buyukdevrim, Ahmet

doi:10.2169/internalmedicine.50.4753

Adipose Tissue Gene Expression of Adiponectin, Tumor Necrosis Factor-alpha and Leptin in Metabolic Syndrome Patients with Coronary Artery Disease

Atıf İçin Kopyala

GORMEZ S., DEMIRKAN A., Atalar F. , Caynak B., ERDIM R., SÖZER V., et al.

INTERNAL MEDICINE, cilt.50, ss.805-810, 2011 (SCI İndekslerine Giren Dergi)

Cilt numarası: 50 Konu: 8
Basım Tarihi: 2011
Doi Numarası: 10.2169/internalmedicine.50.4753
Dergi Adı: INTERNAL MEDICINE
Sayfa Sayısı: ss.805-810

Özet

Objective Metabolic syndrome (MS) is associated with an increased risk of coronary artery disease (CAD) and type 2 diabetes mellitus (DM). In MS, adipose tissue has been shown to function as a paracrine and an endocrine organ secreting various adipocytokines. In the current study, adiponectin, tumor necrosis factor-alpha (TNF-alpha) and leptin gene expressions in the epicardial adipose tissue (EAT), paracardial adipose tissue (PAT) and subcutaneous adipose tissue (SAT) were investigated in MS patients with CAD and in non-MS patients without CAD.