Adipose Tissue Gene Expression of Adiponectin, Tumor Necrosis Factor-alpha and Leptin in Metabolic Syndrome Patients with Coronary Artery Disease

GORMEZ S., DEMIRKAN A., Atalar F., Caynak B., ERDIM R., SÖZER V., ...More

INTERNAL MEDICINE, vol.50, no.8, pp.805-810, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 8
  • Publication Date: 2011
  • Doi Number: 10.2169/internalmedicine.50.4753
  • Journal Name: INTERNAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.805-810
  • Keywords: metabolic syndrome, atherosclerosis, chemokines, inflammation, genes, IN-VIVO, ADIPOCYTOKINES, PROTEIN, WEIGHT, RISK
  • Istanbul University Affiliated: Yes

Abstract

Objective Metabolic syndrome (MS) is associated with an increased risk of coronary artery disease (CAD) and type 2 diabetes mellitus (DM). In MS, adipose tissue has been shown to function as a paracrine and an endocrine organ secreting various adipocytokines. In the current study, adiponectin, tumor necrosis factor-alpha (TNF-alpha) and leptin gene expressions in the epicardial adipose tissue (EAT), paracardial adipose tissue (PAT) and subcutaneous adipose tissue (SAT) were investigated in MS patients with CAD and in non-MS patients without CAD.