Tetanus and diphtheria immunity among term and preterm infant-mother pairs in Turkey, a country where maternal and neonatal tetanus have recently been eliminated

Erener-Ercan T., Aslan M., Vural M., Erginoz E., Kocazeybek B. S. , Ercan G., ...More

EUROPEAN JOURNAL OF PEDIATRICS, vol.174, no.3, pp.339-344, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 174 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.1007/s00431-014-2400-9
  • Page Numbers: pp.339-344


The aim of our study was to investigate the anti-tetanus and anti-diphtheria antibody titres and the placental transfer of these antibodies in a group of vaccinated and unvaccinated mothers and their term or preterm offsprings. Anti-tetanus and anti-diphtheria toxoid IgG antibodies were measured quantitatively by ELISA in 91 infant-mother pairs. Protective concentrations of anti-tetanus and anti-diphtheria were found in 58.3 and 50 % of mothers in the unvaccinated group and 94.5 and 85.5 % of the mothers in the vaccinated group. Protective concentrations were found in 63.9 and 50 % of cord samples, respectively, in the unvaccinated group and in 96.4 and 85.5 % of cord samples, respectively, in the vaccinated group (p = 0.0001). There were no differences in the maternal and cord geometric mean concentrations (GMCs) of anti-toxoid antibodies between those who received two doses or one dose of Td. The GMCs of maternal and cord anti-tetanus and anti-diphtheria were statistically similar between preterm and term groups. Placental transfer ratios (TR) for anti-tetanus and anti-diphtheria were 175 and 150 %, respectively, in the preterm group and 213 and 178 %, respectively, in the term group. There was a strong correlation between maternal and cord anti-toxoid antibody levels. Maternal vaccination was the only predictor of having protective concentrations of anti-toxoid antibodies in cord blood.