Effects of Caffeine on Splanchnic Oxygenation in Preterm Infants

Ilhan O., Bor M.

AMERICAN JOURNAL OF PERINATOLOGY, cilt.38, sa.10, ss.1062-1069, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 10
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1055/s-0040-1701610
  • Dergi Adı: AMERICAN JOURNAL OF PERINATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1062-1069
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Objective The aim of this study is to assess the effects of administering 20mg/kg loading dose of caffeine citrate intravenously on splanchnic oxygenation in preterm infants. Study Design The infants with a gestational age (GA) of <34 weeks who were administered with a 20mg/kg intravenous loading dose of caffeine citrate within 48hours after birth were investigated prospectively. Regional splanchnic oxygen saturation (rsSO (2) ) and splanchnic fractional tissue oxygen extraction rate (sFTOE) were measured using near-infrared spectroscopy before caffeine infusion, immediately after caffeine infusion and 1, 2, 3, 4, and 6hours (h) after dose completion; postdose values were compared with predose values. Results A total of 41 infants with a mean GA of 29.21.6 weeks and birth weight of 1,315257g as well as postnatal age of 32.2 +/- 10.8hours were included in the study. rsSO (2) significantly reduced from 63.1 to 57.5% immediately after caffeine infusion, 55.1% after 1hour, and 55.2% after 2hours with partial recovery at 3-hour postdose. sFTOE increased correspondingly. Conclusion Caffeine reduces splanchnic oxygenation and increases splanchnic oxygen extraction for at least 2hours with partial recovery to predose levels at 3-hour postdose.