Distribution of common CARD15 variants in patients with sporadic Crohn's disease: Cases from Turkey

Uyar F. A., Over-Hamzaoglu H., Ture F., Gul A., Tozun N., Saruhan-Direskeneli G.

DIGESTIVE DISEASES AND SCIENCES, cilt.51, sa.4, ss.706-710, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 4
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1007/s10620-006-3195-y
  • Dergi Adı: DIGESTIVE DISEASES AND SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.706-710
  • Anahtar Kelimeler: CARD15/NOD2, Crohn's disease, inflammatory bowel disease, Turkey, INFLAMMATORY-BOWEL-DISEASE, JAPANESE PATIENTS, NOD2 GENE, MUTATIONAL ANALYSIS, HAPLOTYPE STRUCTURE, ASSOCIATION, POPULATION, SUSCEPTIBILITY, NOD2/CARD15, GENOTYPE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Three common genetic variations, namely, R702W, G908R, and 1007fs, on CARD15 have been shown to increase the risk for Crohn's disease (CD) in Caucasian populations. In this study the frequencies of these CARD15 variants were determined by genotyping in 56 patients with CD and 100 healthy ethnically matched controls from Turkey. Overall frequency of all three variants was 10.7% in CD patients, compared with 1.5% in controls (odds ratio [OR]: 7.9). Among them, the frequency of the G908R variant allele was 8% in CD cases, compared with 0% in controls (OR: 36.8). The allele frequencies of three CD-related CARD15 variants were considerably lower in the control group compared to the reported Caucasian populations. Among the described CARD15 variants, G908R confers an increased susceptibility to CD, whereas the more frequently reported associations in Europeans with R702W and 1007fs are not confirmed in this Turkish population.