Akademik Veri Yönetim Sistemi
Gynecologic oncology, cilt.201, ss.102-108, 2025 (SCI-Expanded, Scopus)
Objective: To evaluate the oncologic and surgical outcomes of the Total Retroperitoneal en-Bloc Resection of Multivisceral-Peritoneal Packet (TROMP) technique in patients with advanced epithelial ovarian cancer. Methods: This retrospective cohort study included 75 patients with FIGO stage III–IV epithelial ovarian cancer who underwent primary cytoreductive surgery using the TROMP approach between January 2017 and December 2023. The TROMP procedure involved systematic en-bloc resection of the parietal peritoneum to eliminate both visible and potential microscopic disease. Perioperative morbidity, adjuvant treatment, and survival data were collected. Postoperative complications were assessed using the Clavien–Dindo classification, and survival was estimated with the Kaplan–Meier method. Results: Complete cytoreduction was achieved in 86.7 % of patients. At a median follow-up of 31 months, the median progression-free survival (PFS) was 30 months and median overall survival (OS) was 77 months. The estimated 2-, 3-, and 5-year PFS rates were 57.2 %, 48.8 %, and 22.6 %, respectively, while 2-, 3-, and 5-year OS rates were 85.6 %, 73.6 %, and 60.8 %. Conclusions: The TROMP procedure demonstrated high rates of complete resection with acceptable morbidity and promising survival outcomes in patients with advanced ovarian cancer. These favorable results may be attributed not only to the extent of cytoreduction, but also to the systematic removal of peritoneal surfaces, including those appearing macroscopically normal, and the use of a no-touch surgical approach that may help reduce tumor cell dissemination. These findings support the reproducibility of the surgical and oncologic outcomes previously reported for this technique.