Asymmetric dimethylarginine (ADMA) levels are increased in patients with fibromyalgia: Correlation with tumor necrosis factor-alpha (TNF-alpha) and 8-iso-prostaglandin F-2 alpha (8-iso-PGF(2 alpha))
CLINICAL BIOCHEMISTRY, vol.44, pp.364-367, 2011 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 44
- Publication Date: 2011
- Doi Number: 10.1016/j.clinbiochem.2011.01.011
- Journal Name: CLINICAL BIOCHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.364-367
- Keywords: Fibromyalgia, ADMA, TNF-alpha, IL-6, 8-iso-PGF(2 alpha), NITRIC-OXIDE LEVELS, OXIDATIVE STRESS, ENDOTHELIAL DYSFUNCTION, RHEUMATOID-ARTHRITIS, IMPACT QUESTIONNAIRE, ELEVATED PLASMA, DISEASES, ANTIOXIDANTS, PREVALENCE, CYTOKINES
- Istanbul University Affiliated: Yes
Abstract
OBJECTIVE:
The aim of the study was to investigate serum levels of asymmetric dimethylarginine (ADMA), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and plasma levels of 8-iso-prostaglandin F(2α) (8-iso-PGF(2α)) in patients with fibromyalgia.
DESIGN AND METHOD:
Twenty-seven patients with fibromyalgia and twenty healthy controls were enrolled in this study. ADMA, TNF-α, IL-6 and 8-iso-PGF(2α) levels were measured by enzyme-linked immunosorbent assay (ELISA).
RESULTS:
Serum levels of ADMA and TNF-α and plasma levels 8-iso-PGF(2α) were significantly increased in patients with fibromyalgia compared to controls. However, no significant difference was observed in IL-6 levels between the two groups. ADMA concentrations were positively correlated with TNF-α and 8-iso-PGF(2α) levels in patients with fibromyalgia.
CONCLUSION:
This is the first study reporting that ADMA levels are significantly elevated in patients with fibromyalgia in association with increased 8-iso-PGF(2α) and TNF-α concentrations. Thereby, ADMA could be suggested as a reliable marker of endothelial dysfunction in patients with fibromyalgia.