Asymmetric dimethylarginine (ADMA) levels are increased in patients with fibromyalgia: Correlation with tumor necrosis factor-alpha (TNF-alpha) and 8-iso-prostaglandin F-2 alpha (8-iso-PGF(2 alpha))


Topal G. , Dönmez A. A. , Dogan B. S. U. , Kucur M., Cengiz D. T. , Berkoz F. B. , ...Daha Fazla

CLINICAL BIOCHEMISTRY, cilt.44, ss.364-367, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Objective: The aim of the study was to investigate serum levels of asymmetric dimethylarginine (ADMA), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and plasma levels of 8-iso-prostaglandin F-2 alpha (8-iso-PGF(2 alpha),) in patients with fibromyalgia.

OBJECTIVE:

The aim of the study was to investigate serum levels of asymmetric dimethylarginine (ADMA), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and plasma levels of 8-iso-prostaglandin F(2α) (8-iso-PGF(2α)) in patients with fibromyalgia.

DESIGN AND METHOD:

Twenty-seven patients with fibromyalgia and twenty healthy controls were enrolled in this study. ADMA, TNF-α, IL-6 and 8-iso-PGF(2α) levels were measured by enzyme-linked immunosorbent assay (ELISA).

RESULTS:

Serum levels of ADMA and TNF-α and plasma levels 8-iso-PGF(2α) were significantly increased in patients with fibromyalgia compared to controls. However, no significant difference was observed in IL-6 levels between the two groups. ADMA concentrations were positively correlated with TNF-α and 8-iso-PGF(2α) levels in patients with fibromyalgia.

CONCLUSION:

This is the first study reporting that ADMA levels are significantly elevated in patients with fibromyalgia in association with increased 8-iso-PGF(2α) and TNF-α concentrations. Thereby, ADMA could be suggested as a reliable marker of endothelial dysfunction in patients with fibromyalgia.