Association of Myocardial T1/T2 Mapping Abnormalities With Late Gadolinium Enhancement and Left Ventricular Function
Van Medical Journal, cilt.33, sa.2, ss.181-188, 2026 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.5505/vmj.2026.68553
- Dergi Adı: Van Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.181-188
- Anahtar Kelimeler: edema, fibrosis, Magnetic resonance imaging, myocardium, ventricular function, left
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- İstanbul Üniversitesi Adresli: Evet
Özet
Introduction: To investigate the relationship between visually assessed myocardial late gadolinium enhancem ent (LGE), native T1/T2 myocardial mapping abnormalities, and left ventricular ejection fraction (LVEF) in a heterogeneous adult cardiovascular magnetic resonance (CMR) cohort. Materials and Methods: This retrospective study included consecutive adults referred for clinical CMR with evaluable LGE. LGE presence (yes/no) was used as the comparative reference. Myocardial mapping abnormalities were defined as elevated native T1 and/or T2 values using protocol-specific institutional reference limits derived from healthy controls (non-parametric upper reference limit; 95th percentile). Associations between LGE, mapping findings, and LVEF were assessed using univariable and multiple logistic regre ssion adjusted for age and LVEF. Results: A total of 1,074 consecutive adult patients undergoing clinical CMR were screened. After predefined exclusions, 1,005 patients in whom both late gadolinium enhancement and myocardial T1/T2 mapping were evaluable constituted the final analysis set. Myocardial LGE was present in 54.5%. Myocardial mapping abnormalities were strongly associated with LGE positivity (OR 8.61; 95% CI 6.05– 12.26; p<0.001) and remained independently associated after multiple adjustment for age and LVEF (adjusted OR 7.73; 95% CI 5.38 – 11.10; p<0.001). LGE-positive patients had lower LVEF than LGE-negative patients, and myocardial mapping abnormalities were also associated with lower LVEF. The mapping–LGE association persisted in both preserved and reduced LVEF strata. Conclusion: In a large heterogeneous adult CMR population, T1/T2 myocardial mapping abnormalities show a strong and independent association with visually assessed LGE and ventricular function, supporting mapping as a complementary component of integrate d myocardial tissue characterization.