Serum cystatin C levels in children with nephrosis or diabetes: A pilot study
Journal of Applied Research, vol.4, no.1, pp.135-140, 2004 (Scopus)
- Publication Type: Article / Article
- Volume: 4 Issue: 1
- Publication Date: 2004
- Journal Name: Journal of Applied Research
- Journal Indexes: Scopus
- Page Numbers: pp.135-140
- Keywords: Creatinine, Cystatin C, Nephrosis, Receiver operating characteristic, Type 2 diabetes
- Istanbul University Affiliated: Yes
Abstract
Background: The glomerular filtration rate is the best overall index of renal function in health and disease. Recently, cystatin C, a low molecular weight protein, freely filtered through the glomerulus and almost completely reabsorbed and catabolized by tubular cells, has been proposed as a new and very sensitive serum marker of change in glomerular filtration rate. Methods: This study investigated the relationship between cystatin C and creatinine in nephrotic and diabetic children. Serum cystatin C was determined by particle-enhanced immunoturbidimetry using the cystatin PET-kit. Serum creatinine, urea, and albumin were determined by auto-analyzer. Results: Sensitivity and specificity for the diagnosis of renal impairment (defined as GFR<35.85 mL/min) calculated by a receiver operating characteristic (ROC) curve for serum cystatin C and serum creatinine in all groups. With a cutoff value of 35.85 mL/min, the area under the ROC curve (AUC) was 0.75, 0.76 (respectively) for creatinine, and 0.68, 0.62 (respectively) for cystatin C in nephritic and diabetic group. The AUC was statistically significant between serum cystatin and creatinine. The ROC plot indicates that cystatin c is a better marker than serum creatinine for detecting impaired GFR. There was no correlation between cystatin C and creatinine levels in all groups. Conclusion: Serum cystatin C measurement appears to be equivalent to creatinine as a marker for estimating the glomerular filtration rate in children with nephritis and diabetes.