Akademik Veri Yönetim Sistemi
Journal of Applied Research, cilt.4, sa.1, ss.135-140, 2004 (Scopus)
Background: The glomerular filtration rate is the best overall index of renal function in health and disease. Recently, cystatin C, a low molecular weight protein, freely filtered through the glomerulus and almost completely reabsorbed and catabolized by tubular cells, has been proposed as a new and very sensitive serum marker of change in glomerular filtration rate. Methods: This study investigated the relationship between cystatin C and creatinine in nephrotic and diabetic children. Serum cystatin C was determined by particle-enhanced immunoturbidimetry using the cystatin PET-kit. Serum creatinine, urea, and albumin were determined by auto-analyzer. Results: Sensitivity and specificity for the diagnosis of renal impairment (defined as GFR<35.85 mL/min) calculated by a receiver operating characteristic (ROC) curve for serum cystatin C and serum creatinine in all groups. With a cutoff value of 35.85 mL/min, the area under the ROC curve (AUC) was 0.75, 0.76 (respectively) for creatinine, and 0.68, 0.62 (respectively) for cystatin C in nephritic and diabetic group. The AUC was statistically significant between serum cystatin and creatinine. The ROC plot indicates that cystatin c is a better marker than serum creatinine for detecting impaired GFR. There was no correlation between cystatin C and creatinine levels in all groups. Conclusion: Serum cystatin C measurement appears to be equivalent to creatinine as a marker for estimating the glomerular filtration rate in children with nephritis and diabetes.