Prevalence and management of hypertension in Turner syndrome: data from the International Turner Syndrome (I-TS) registry

Mathara Diddhenipothage S. A. D., Beck K. J., Amiyangoda G., Bryce J., Cima L., De Groote K., ...Daha Fazla

ENDOCRINE CONNECTIONS, cilt.14, sa.2, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 2
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1530/ec-24-0477
  • Dergi Adı: ENDOCRINE CONNECTIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Directory of Open Access Journals
  • Anahtar Kelimeler: hypertension, International Turner Syndrome Registry, Turner syndrome
  • İstanbul Üniversitesi Adresli: Evet

Özet

IntroductionCardiovascular disease is the most common cause of death in Turner syndrome (TS) for which arterial hypertension has a direct influence and is a key modifiable risk factor.ObjectiveTo investigate the prevalence and patterns of hypertension diagnosis and management in adult patients with TS who are registered in a large international multicentre database (TS-HTN study).MethodsRetrospective multicentre observational study of patients aged >= 18 years included in the I-TS (International-TS) registry (2020-2022), using registry and participating centre-collected data.ResultsTwelve international centres participated, including 182 patients with a median age of 28 years (IQR 23-37.2). Arterial hypertension was recorded in 13.2% (n = 24). The median age at hypertension diagnosis was 27 years (range 10-56), with 92% aged less than 50 years at diagnosis. The majority (75%) were classified as primary hypertension (n = 18). In binomial regression analysis, higher body mass index was the only parameter significantly associated with the occurrence of hypertension (B = 1.487, P = 0.004). Among patients with aortic disease (n = 9), 50% had systolic BP >= 130 mmHg and 66.6% had diastolic BP >= 80 mmHg during the last clinic review. Angiotensin-converting enzyme inhibitors were the most common (n = 16) medication prescribed, followed by angiotensin receptor blockers (n = 6), beta-blockers (n = 6) and calcium channel blockers (n = 6).ConclusionsArterial hypertension is common in TS and occurs at a young age. Overweight/obesity was a notable risk factor for hypertension. The frequency of suboptimal BP control among high-risk patients highlights the importance of increased awareness and TS-specific consensus guidance on management.