Mannose binding lectin gene 2 (rs1800450) missense variant may contribute to development and severity of COVID-19 infection.

Medetalibeyoglu A., Bahat G., Senkal N., Kose M., Avcı K., Sayın G., ...Daha Fazla

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, cilt.89, ss.104717, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 89
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.meegid.2021.104717
  • Dergi Adı: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, Environment Index, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.104717
  • Anahtar Kelimeler: MBL2, Gene mutation, COVID-19, Hyperinflammation, Cytokine, SARS-CoV-2, C VIRUS-INFECTION, HEPATITIS-C, POLYMORPHISMS, CORONAVIRUS, SUSCEPTIBILITY, ASSOCIATION, SARS-COV-2, PROTEIN, MBL2
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background/objectives: COVID-19 followed a mortal course in some young patients without any underlying factors, however, it followed a very benign course in some very older individuals with multiple comorbidities. These observations question if some genetic factors may be related to the vulnerability and poor prognosis of the disease. In this study, we aimed to investigate whether MBL2 gene B variant at codon 54 (rs1800450) were related to the variabilities in clinical course of this infection.