Can Ultrasound Imaging Predict the Success of an Experimental Steatofibrosis Model?

Turkay R., Aydin A., Bingul İ., Kucukgergin C., Dogan-Ekici I., Hocaoglu E., ...Daha Fazla

ULTRASOUND QUARTERLY, cilt.33, sa.2, ss.157-161, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1097/ruq.0000000000000286
  • Dergi Adı: ULTRASOUND QUARTERLY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.157-161
  • Anahtar Kelimeler: hepatosteatosis, ultrasonography, 2-hit model, rat, FATTY LIVER-DISEASE, NONALCOHOLIC STEATOHEPATITIS, CARBON-TETRACHLORIDE, FIBROSIS, DIET, TALE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Our goal was to evaluate the role of ultrasound (US) imaging in an experimental 2-hit steatofibrosis rat model. Nineteen female Sprague-Dawley rats were divided into 2 groups: control group (n = 6) and high-fat diet carbontetrachloride (HFD-CCl4) group (n = 13) that was fed with HFD for 14 weeks. Ultrasound was performed to evaluate liver steatosis. The HFD-CCl4 group rats were divided further into 2 subgroups: HFD rats with liver steatosis [US (+) group; n = 6] and without steatosis [US (-) group; n = 7]. All rats in the subgroups were administered with CCl4. In both US(+) and US(-) subgroups, steatosis score, fibrosis score, triglyceride, and hydroxyproline contents were markedly higher compared with the control group. When compared with the US (-) group, triglyceride and hydroxyproline contents were significantly higher in the US (+) group, whereas steatosis and fibrosis scores were not different. Ultrasound imaging may be useful to assess the success of a 2-hit experimental steatofibrosis model.