Microrna analysis of human decidua mesenchymal stromal cells from preeclampsia patients

Kamali Simsek N., BENİAN A., Sevgin K., Ergun Y., Celik H. G., Karahuseyinoglu S., ...More

PLACENTA, vol.115, pp.12-19, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 115
  • Publication Date: 2021
  • Doi Number: 10.1016/j.placenta.2021.09.004
  • Journal Name: PLACENTA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.12-19
  • Keywords: Preeclampsia, Human decidua mesenchymal stromal cell, MicroRNA, Droplet digital PCR, STEM-CELLS, CHORIONIC VILLI, EXPRESSION, PLACENTA, MIR-16, FETAL, ANGIOGENESIS, PREGNANCIES, DIFFERENTIATION, PROLIFERATION
  • Istanbul University Affiliated: Yes

Abstract

Introduction: In preeclampsia (PE), human decidua mesenchymal stromal cells (hDMSCs) are exposed to abnormally high levels of oxidative stress and inflammatory factors circulating in the maternal blood. MicroRNAs (miRNAs) have been shown to have a significant impact on the differentiation, maturation and function of mesenchymal stromal cells (MSCs). Our aim in the present study is firstly to investigate differentially expressed miRNA levels to be used as a biomarker in the early detection of PE and secondly to investigate whether those differentially expressed miRNAs in hDMSCs have an effect on the pathogenesis of PE.