Electrospinning method to produce drug-loaded nanofibers for topical/ transdermal drug delivery applications

Esenturk I., Erdal M. S., Gungor S.

ISTANBUL JOURNAL OF PHARMACY, cilt.46, sa.1, ss.49-68, 2016 (ESCI) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 46 Sayı: 1
  • Basım Tarihi: 2016
  • Dergi Adı: ISTANBUL JOURNAL OF PHARMACY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.49-68
  • İstanbul Üniversitesi Adresli: Evet

Özet

Electrospinning is the method for preparing drug-loaded nanofibers with ultrafine structure, a large surface area to volume ratio, and a high porosity with a small pore size. Among the other nanofiber production methods, electrospinning is the most cost effective one with simple tooling and, it is applicable to produce ultrafine fibers with a simple step-up production for drug delivery applications. The selection of the polymer as carrier for electrospinning and the production procedure design is crucial due to drug-polymer-solvent interactions and the other process parameters which would influence the physicochemical biocompatibilityand characteristics. This technique can be applied to produce nanofibers of a wide array of polymer types: natural, synthetic polymers, or their blends. This review focuses on various electrospinning methods to produce drug loaded nanofibers, polymers used, electrospinning process parameters, their advantages and limitations for topical/transdermal drug delivery applications.