Electrospinning method to produce drug-loaded nanofibers for topical/ transdermal drug delivery applications
ISTANBUL JOURNAL OF PHARMACY, vol.46, no.1, pp.49-68, 2016 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Review
- Volume: 46 Issue: 1
- Publication Date: 2016
- Journal Name: ISTANBUL JOURNAL OF PHARMACY
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.49-68
- Istanbul University Affiliated: Yes
Abstract
Electrospinning is the method for preparing drug-loaded nanofibers with ultrafine structure, a large surface area to volume ratio, and a high porosity with a small pore size. Among the other nanofiber production methods, electrospinning is the most cost effective one with simple tooling and, it is applicable to produce ultrafine fibers with a simple step-up production for drug delivery applications. The selection of the polymer as carrier for electrospinning and the production procedure design is crucial due to drug-polymer-solvent interactions and the other process parameters which would influence the physicochemical biocompatibilityand characteristics. This technique can be applied to produce nanofibers of a wide array of polymer types: natural, synthetic polymers, or their blends. This review focuses on various electrospinning methods to produce drug loaded nanofibers, polymers used, electrospinning process parameters, their advantages and limitations for topical/transdermal drug delivery applications.