Electrospinning method to produce drug-loaded nanofibers for topical/ transdermal drug delivery applications


Esenturk I., Erdal M. S. , Gungor S.

ISTANBUL JOURNAL OF PHARMACY, vol.46, no.1, pp.49-68, 2016 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Review
  • Volume: 46 Issue: 1
  • Publication Date: 2016
  • Title of Journal : ISTANBUL JOURNAL OF PHARMACY
  • Page Numbers: pp.49-68

Abstract

Electrospinning is the method for preparing drug-loaded nanofibers with ultrafine structure, a large surface area to volume ratio, and a high porosity with a small pore size. Among the other nanofiber production methods, electrospinning is the most cost effective one with simple tooling and, it is applicable to produce ultrafine fibers with a simple step-up production for drug delivery applications. The selection of the polymer as carrier for electrospinning and the production procedure design is crucial due to drug-polymer-solvent interactions and the other process parameters which would influence the physicochemical biocompatibilityand characteristics. This technique can be applied to produce nanofibers of a wide array of polymer types: natural, synthetic polymers, or their blends. This review focuses on various electrospinning methods to produce drug loaded nanofibers, polymers used, electrospinning process parameters, their advantages and limitations for topical/transdermal drug delivery applications.