An association of the MCP-1 and CCR2 gene polymorphisms with oral lichen planus.
Oral surgery, oral medicine, oral pathology and oral radiology, cilt.132, ss.708-714, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 132
- Basım Tarihi: 2021
- Doi Numarası: 10.1016/j.oooo.2021.06.009
- Dergi Adı: Oral surgery, oral medicine, oral pathology and oral radiology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.708-714
- İstanbul Üniversitesi Adresli: Evet
Özet
Objective. The purpose of this study was to investigate the frequency of monocyte chemoattractant protein (MCP)-1 CCR2 gene Study Design. A cohort of 50 patients with OLP and 142 control participants without OLP were recruited to investigate the frequency of MCP-1 and CCR2 gene polymorphisms. Chi-square and Fisher's exact tests were used. Student t test and analysis of variance were used to compare demographic data between groups. Results. The MCP AA genotype was less common in the patient group (52%) than in the control group (66.2%; odds ratio [OR] = 0.553; 95% confidence interval [CI], 0.287-1.065; P = .075). The MCP G allele was higher in the patient group (48%) than in the control group (33.8%; OR = 1.808; 95% CI, 0.939-3.479; P= .075). The frequency of the MCP GG genotype was observed to be higher in the patient group (4%) than in the controls (0.7%; OR: 5.875, 95% CI:0.521-66,24; p = 0.106). The CCR2 64I64I genotype was more common in the patient group (6%) than in the control group (2.8%). All results were not statistically significant. Conclusion. We suggest that the G allele of MCP-1 and 64I64I genotype of CCR2 polymorphisms do not pose an increased risk for 2021;132:708-714)