Inflammation and oxidative stress are key mediators in AKB48-induced neurotoxicity in vitro

Oztas E., Abudayyak M. F., Celiksoz M., Ozhan G.

TOXICOLOGY IN VITRO, cilt.55, ss.101-107, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.tiv.2018.12.005
  • Dergi Adı: TOXICOLOGY IN VITRO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.101-107
  • Anahtar Kelimeler: AKB48, SH-SY5Y cell line, Oxidative damage, Apoptosis, SYNTHETIC CANNABINOIDS, SPICE PRODUCTS, CELLS, CYTOTOXICITY, METABOLISM, DRUGS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Synthetic cannabinoids were introduced into market in early 2000s; since these "legal highs" are dramatically popular among youth, it becomes a deadly problem. Synthetic cannabinoids have high affinity to cannabinoid receptors; leading to various clinical symptoms. AKB48 (Apinaca) has been classified as a third-generation synthetic cannabinoid for the first time in 2014.