Inflammation and oxidative stress are key mediators in AKB48-induced neurotoxicity in vitro
TOXICOLOGY IN VITRO, cilt.55, ss.101-107, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 55
- Basım Tarihi: 2019
- Doi Numarası: 10.1016/j.tiv.2018.12.005
- Dergi Adı: TOXICOLOGY IN VITRO
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.101-107
- Anahtar Kelimeler: AKB48, SH-SY5Y cell line, Oxidative damage, Apoptosis, SYNTHETIC CANNABINOIDS, SPICE PRODUCTS, CELLS, CYTOTOXICITY, METABOLISM, DRUGS
- İstanbul Üniversitesi Adresli: Evet
Özet
Synthetic cannabinoids were introduced into market in early 2000s; since these "legal highs" are dramatically popular among youth, it becomes a deadly problem. Synthetic cannabinoids have high affinity to cannabinoid receptors; leading to various clinical symptoms. AKB48 (Apinaca) has been classified as a third-generation synthetic cannabinoid for the first time in 2014.