Effects of nimodipine and pentoxyfylline in prevention of hepatic ischemic damage in rats at normal and hypothermic conditions

Kaptanoglu, Levent; Kapan, Metin; Kapan, Selin; Goksoy, Ertuğrul; Oktar, Huseyin

doi:10.1016/j.ejphar.2008.02.074

Effects of nimodipine and pentoxyfylline in prevention of hepatic ischemic damage in rats at normal and hypothermic conditions

Kaptanoglu L., Kapan M., Kapan S., Goksoy E., Oktar H.

EUROPEAN JOURNAL OF PHARMACOLOGY, vol.587, pp.253-256, 2008 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 587
Publication Date: 2008
Doi Number: 10.1016/j.ejphar.2008.02.074
Journal Name: EUROPEAN JOURNAL OF PHARMACOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.253-256
Istanbul University Affiliated: Yes

Abstract

Hepatic ischemia should be considered in serious liver injury, liver tumor resection and liver transplantation. There are other conditions that decrease hepatic blood flow and cause hepatic ischemia, such as hemorrhagic shock, sepsis, hepatic artery ligation, trauma, and certain vascular lesions. In this study, effects of nimodipine (a calcium channel blocker) and pentoxyfylline (a derivative of methylxanthine) on duration and degree of hepatic ischemia in rats at normothermic and hypothermic conditions are investigated.