INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, cilt.58, sa.7, ss.659-661, 2004 (SCI-Expanded)
Objectives: The occurrence of lamivudine resistance is often associated with the clinical breakthrough, which is characterised by the reappearance of hepatitis B virus (HBV) DNA in serum and the elevation of aminotransferases. We evaluated the efficacy of alpha interferon for clinical breakthrough in patients receiving lamivudine therapy.