EGFR mutation testing using archival-stained smears in non-small cell lung carcinoma

Ozluk Y., Firat P., Yegen G., Hocaoglu J., Tas S., Yilmazbayhan D.

CYTOPATHOLOGY, vol.28, no.1, pp.35-45, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.1111/cyt.12357
  • Journal Name: CYTOPATHOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.35-45
  • Keywords: lung cancer, epidermal growth factor receptor, molecular, cytology, TTF-1, GROWTH-FACTOR RECEPTOR, THYROID TRANSCRIPTION FACTOR-1, CYTOLOGY SPECIMENS, GENE-MUTATIONS, PROGNOSTIC-FACTOR, CANCER, SAMPLES, CLASSIFICATION, CYTOPATHOLOGY, GEFITINIB
  • Istanbul University Affiliated: Yes

Abstract

Objective: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have shown benefits regarding progression-free and overall survival in patients whose tumours show EGFR mutations. Most patients' lung cancer is metastatic when detected. Small tissue samples and cytological materials are widely used in diagnosis. The aim of the present study was to compare the EGFR mutation analysis results between cytology, small biopsies and resections.