Malignant Transformation of Parotid Gland Non-sebaceous Lymphadenoma: Case Report and Review of Literature
Head and Neck Pathology, vol.14, no.4, pp.1123-1128, 2020 (ESCI, Scopus)
- Publication Type: Article / Article
- Volume: 14 Issue: 4
- Publication Date: 2020
- Doi Number: 10.1007/s12105-020-01133-3
- Journal Name: Head and Neck Pathology
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, MEDLINE
- Page Numbers: pp.1123-1128
- Keywords: Non-sebaceous, Lymphadenoma, Parotid, Malignant transformation, SALIVARY-GLAND, NONSEBACEOUS LYMPHADENOMA, DIFFERENTIATION, TUMOR
- Istanbul University Affiliated: Yes
Abstract
Non-sebaceous lymphadenoma is a sporadic benign tumor of salivary glands. Histopathologic and immunohistochemical properties, diagnostic criteria, and theories for the histologic origin of the disease have been defined and well-discussed in the literature. However, none of the cases showed malignant transformation to date. We reported a case of 54 years old female patient with a right preauricular mass. Magnetic resonance imaging demonstrated a 2 cm, well-defined contrast-enhanced mass in the right parotid gland. Fine needle aspiration cytology was undiagnostic but suspicious for malignancy. Total parotidectomy with facial nerve preservation was done. In the histopathological examination, non-sebaceous lymphadenoma regions and malignant cells with abundant cytoplasm, large vesicular nuclei, and prominent nucleoli, which occupied approximately 70% of the mass, were seen. The diagnosis was undifferentiated carcinoma arisen from non-sebaceous lymphadenoma. Adjuvant radiotherapy was given. No recurrence was detected during ten months of follow-up. This case is the first case of a malignancy developed from non-sebaceous lymphadenoma.