Sensitive Determination of 5-Fluorouracil with Anion Exchange Solid-Phase Extraction and a Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene/VO<sub>2</sub>@MoO<sub>2</sub> Electrochemical Sensor

AVAN A. A., Filik H.

ANALYTICAL LETTERS, vol.59, no.5, pp.800-824, 2026 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 5
  • Publication Date: 2026
  • Doi Number: 10.1080/00032719.2025.2507787
  • Journal Name: ANALYTICAL LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, Chimica
  • Page Numbers: pp.800-824
  • Istanbul University Affiliated: Yes

Abstract

Solid-phase extraction with an anion exchange resin was used together with electrochemical detection on a glassy carbon electrode that was modified with Ti3C2TxMXene /VO2@MoO2 composites to measure 5-fluorouracil. The VO2@MoO2 composites were synthesized via a precipitation process combined with the hydrothermal method. The nanomaterials were characterized in terms of their structure, composition, and morphology. The key processing parameters affecting the solid-phase extraction and electrochemical determination were optimized. The linear response was from 0.01 to 35 mu M, with a detection limit of 2.2 nM. The proposed method was applied to determine 5-fluorouracil in urine and water samples with satisfactory recoveries (90-92%).