Monte Carlo simulation for statistical mechanics model of ion-channel cooperativity in cell membranes

Erdem R. , Aydiner E.

PHYSICAL REVIEW E, cilt.79, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier


Voltage-gated ion channels are key molecules for the generation and propagation of electrical signals in excitable cell membranes. The voltage-dependent switching of these channels between conducting and nonconducting states is a major factor in controlling the transmembrane voltage. In this study, a statistical mechanics model of these molecules has been discussed on the basis of a two-dimensional spin model. A new Hamiltonian and a new Monte Carlo simulation algorithm are introduced to simulate such a model. It was shown that the results well match the experimental data obtained from batrachotoxin-modified sodium channels in the squid giant axon using the cut-open axon technique.