Testing for EGFR Mutations and ALK Rearrangements in Advanced Non-Small-Cell Lung Cancer: Considerations for Countries in Emerging Markets

Dalurzo M. L., Aviles-Salas A., Soares F. A., Hou Y., Li Y., Stroganova A., ...Daha Fazla

ONCOTARGETS AND THERAPY, cilt.14, ss.4671-4692, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 14
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2147/ott.s313669
  • Dergi Adı: ONCOTARGETS AND THERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.4671-4692
  • Anahtar Kelimeler: non-small-cell lung cancer, EGFR testing, ALK testing, immunohistochemistry, FISH, next-generation sequencing, TYROSINE KINASE INHIBITORS, FACTOR RECEPTOR MUTATIONS, ANAPLASTIC LYMPHOMA KINASE, CIRCULATING TUMOR DNA, REAL-WORLD, INTERNATIONAL ASSOCIATION, EML4-ALK REARRANGEMENT, TREATMENT PATTERNS, RUSSIAN PATIENTS, T790M MUTATION
  • İstanbul Üniversitesi Adresli: Hayır

Özet

The treatment of patients with advanced non-small-cell lung cancer (NSCLC) in recent years has been increasingly guided by biomarker testing. Testing has centered on driver genetic alterations involving the epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) rearrangements. The presence of these mutations is predictive of response to targeted therapies such as EGFR tyrosine kinase inhibitors (TKIs) and ALK TKIs. However, there are substantial challenges for the implementation of biomarker testing, particularly in emerging countries. Understanding the barriers to testing in NSCLC will be key to improving molecular testing rates worldwide and patient outcomes as a result. In this article, we review EGFR mutations and ALK rearrangements as predictive biomarkers for NSCLC, discuss a selection of appropriate tests and review the literature with respect to the global uptake of EGFR and ALK testing. To help improve testing rates and unify procedures, we review our experiences with biomarker testing in China, South Korea, Russia, Turkey, Brazil, Argentina and Mexico, and propose a set of recommendations that pathologists from emerging countries can apply to assist with the diagnosis of NSCLC.