Design, synthesis, characterization and antimicrobial evaluation of some novel hydrazinecarbothioamide, 4-thiazolidinone and 1,2,4-triazole-3-thione derivatives

Dincel E. D., Ulusoy-Guzeldemirci N., Satana D., KÜÇÜKBASMACI Ö.

JOURNAL OF HETEROCYCLIC CHEMISTRY, vol.58, no.1, pp.195-205, 2021 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.1002/jhet.4159
  • Journal Name: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Chemical Abstracts Core, Chimica, EMBASE, Index Chemicus (IC)
  • Page Numbers: pp.195-205
  • Istanbul University Affiliated: Yes

Abstract

A series of novel hydrazinecarbothioamide (5a,c,f), 4-thiazolidinone (6a-e), and 1,2,4-triazole-3-thione (7a-d) were designed and synthesized. The structural elucidations of the novel compounds were performed by IR,H-1-NMR,C-13-NMR, mass and elemental analysis. All novel derivatives were evaluated for their antibacterial and antifungal activities against nine diverse microorganisms. According to the biological activity studies of the compounds,6d,7cand7ddisplayed hope promising antibacterial activity. Furthermore,6ddisplayed potent antifungal activity. Consequently, the obtained results revealed that6d,7cand7dpresent a leading structure for future drug development due to its straightforward synthesis and relevant bioactivity.