Coexistence of homozygous factor V Leiden mutation and antiphospholipid antibodies in two patients presented with Budd-Chiari syndrome
HAEMATOLOGIA, cilt.32, sa.1, ss.73-77, 2002 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 1
- Basım Tarihi: 2002
- Doi Numarası: 10.1163/156855902760262790
- Dergi Adı: HAEMATOLOGIA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.73-77
- Anahtar Kelimeler: antiphospholipid antibodies, Budd-Chiari syndrome, homozygous factor V Leiden mutation, portal vein thrombosis, recurrent fetal loss, splenic vein thrombosis, ACTIVATED PROTEIN-C, VEIN-THROMBOSIS, RESISTANCE, PROTHROMBIN, PREVALENCE
- İstanbul Üniversitesi Adresli: Evet
Özet
Two female patients are reported, who presented with Budd-Chiari syndrome (hepatic vein thrombosis), and were found to have both, antiphospholipid antibodies and homozygous factor V Leiden mutation. Both patients also had recurrent fetal losses, as well as splenic and portal vein thrombosis, The coexistence of homozygous factor V Leiden mutation and antiphospholipid antibodies in patients with Budd-Chiari syndrome is extremely rare. The interaction of antiphospholipid antibodies and factor V Leiden mutation in the pathogenesis of antiphospholipid syndrome and their contribution to Budd-Chiari syndrome are discussed.