Coexistence of homozygous factor V Leiden mutation and antiphospholipid antibodies in two patients presented with Budd-Chiari syndrome


Diz-Kucukkaya R., Demir K., Yenerel M. N. , Nalcaci M., Kaymakoglu S., Inanc M.

HAEMATOLOGIA, vol.32, no.1, pp.73-77, 2002 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 1
  • Publication Date: 2002
  • Doi Number: 10.1163/156855902760262790
  • Journal Name: HAEMATOLOGIA
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.73-77
  • Keywords: antiphospholipid antibodies, Budd-Chiari syndrome, homozygous factor V Leiden mutation, portal vein thrombosis, recurrent fetal loss, splenic vein thrombosis, ACTIVATED PROTEIN-C, VEIN-THROMBOSIS, RESISTANCE, PROTHROMBIN, PREVALENCE

Abstract

Two female patients are reported, who presented with Budd-Chiari syndrome (hepatic vein thrombosis), and were found to have both, antiphospholipid antibodies and homozygous factor V Leiden mutation. Both patients also had recurrent fetal losses, as well as splenic and portal vein thrombosis, The coexistence of homozygous factor V Leiden mutation and antiphospholipid antibodies in patients with Budd-Chiari syndrome is extremely rare. The interaction of antiphospholipid antibodies and factor V Leiden mutation in the pathogenesis of antiphospholipid syndrome and their contribution to Budd-Chiari syndrome are discussed.