Coexistence of homozygous factor V Leiden mutation and antiphospholipid antibodies in two patients presented with Budd-Chiari syndrome


Diz-Kucukkaya R., Demir K. , Yenerel M. N. , Nalcaci M. , Kaymakoglu S. , Inanc M.

HAEMATOLOGIA, cilt.32, sa.1, ss.73-77, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 32 Konu: 1
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1163/156855902760262790
  • Dergi Adı: HAEMATOLOGIA
  • Sayfa Sayıları: ss.73-77

Özet

Two female patients are reported, who presented with Budd-Chiari syndrome (hepatic vein thrombosis), and were found to have both, antiphospholipid antibodies and homozygous factor V Leiden mutation. Both patients also had recurrent fetal losses, as well as splenic and portal vein thrombosis, The coexistence of homozygous factor V Leiden mutation and antiphospholipid antibodies in patients with Budd-Chiari syndrome is extremely rare. The interaction of antiphospholipid antibodies and factor V Leiden mutation in the pathogenesis of antiphospholipid syndrome and their contribution to Budd-Chiari syndrome are discussed.