Coexistence of homozygous factor V Leiden mutation and antiphospholipid antibodies in two patients presented with Budd-Chiari syndrome

Diz-Kucukkaya R., Demir K., Yenerel M. N., Nalcaci M., Kaymakoglu S., Inanc M.

HAEMATOLOGIA, cilt.32, sa.1, ss.73-77, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 1
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1163/156855902760262790
  • Dergi Adı: HAEMATOLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.73-77
  • Anahtar Kelimeler: antiphospholipid antibodies, Budd-Chiari syndrome, homozygous factor V Leiden mutation, portal vein thrombosis, recurrent fetal loss, splenic vein thrombosis, ACTIVATED PROTEIN-C, VEIN-THROMBOSIS, RESISTANCE, PROTHROMBIN, PREVALENCE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Two female patients are reported, who presented with Budd-Chiari syndrome (hepatic vein thrombosis), and were found to have both, antiphospholipid antibodies and homozygous factor V Leiden mutation. Both patients also had recurrent fetal losses, as well as splenic and portal vein thrombosis, The coexistence of homozygous factor V Leiden mutation and antiphospholipid antibodies in patients with Budd-Chiari syndrome is extremely rare. The interaction of antiphospholipid antibodies and factor V Leiden mutation in the pathogenesis of antiphospholipid syndrome and their contribution to Budd-Chiari syndrome are discussed.