SERUM HS-CRP LEVELS DO NOT INDICATE THE SEVERITY OF LIVER DAMAGE IN NON-ALCOHOLIC STEATOHEPATITIS PATIENTS WITH TYPE-2 DIABETES MELLITUS

Kocabay G., Telci A. G. S., Tuetuencue Y., Tiryaki B., Oezel S., Cevikba U., ...Daha Fazla

NOBEL MEDICUS, cilt.6, sa.2, ss.43-46, 2010 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.atherosclerosis.2009.07.052
  • Dergi Adı: NOBEL MEDICUS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.43-46
  • Anahtar Kelimeler: Non-alcoholic steatohepatitis (NASH), type 2 diabetes mellitus, hs-CRP, liver enzymes, Brunt's classification system, C-REACTIVE PROTEIN, METABOLIC SYNDROME, DISEASE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Non-alcoholic steatohepatitis (NASH) is a commonly encountered community health problem which is associated with obesity, insulin resistance and type 2 diabetes. There is no clinical or biochemical indicator predicting the prognosis of NASH. Therefore, it is not possible to predict the course of NASH in which patients may stay as a benign condition or in which it may progress to fibrosis or rarely cirrhosis. High sensitive C-reactive protein (hs-CRP) is a commonly used acute phase reactant which increases in even mild inflammatory states. In this study, we investigated the relationship between hs-CRP and inflammation in liver tissue in cases with NASH and type 2 diabetes mellitus.