Akademik Veri Yönetim Sistemi
1st International Multidisciplinary Cancer Research Congress, Diyarbakır, Türkiye, 18 - 22 Eylül 2019, ss.152-160
Ovarian
cancer is the fifth most important cause of cancer-related deaths among women
and the most lethal gynecologic malignancy. Epithelial
ovarian cancer (EOC) is asymptomatic and few
screening tests are available. We aimed to identify novel circulating miRNAs to
be used as therapeutic prediction of EOC. Moreover, another goal of our study is the
importance of dysregulated miRNAs in ovarian cyst and their expression profile
difference between ovarian cancer cases. In this study, we studied three
different samples: serums of EOC patients, healthy individuals (HI) and benign
ovarian cysts (BOC). Their miRNA expressions have been compared by microarray.
Microarray data were analyzed according to miRNA expressions the relation
between miRNAs target genes and EOC were examined by bioinformatic tools. 75
and 66 significantly dysregulated miRNAs were identified by microarray in BOC
vs. EOC and BOC vs. HI comparison, respectively. Then, we focused on common
miRNAs that found in both comparison and finally 46 important miRNAs were
detected which can represent the only common sample group, BOC. After these findings,
we also considered miRNA profiling in EOC and HI, and surprisingly any common
miRNAs were found with these 46 miRNAs. Thus, we analyzed them depending on
their potential importance on BOC pathogenesis. After bioinformatic analysis, our
findings indicated that there are several biological processes and pathways
which can be considered to be related BOC development.