Clinical significance of epithelial-mesenchymal transition and cancer stem cells

Topcul M. R., Cetin I.

JOURNAL OF BUON, cilt.21, sa.2, ss.312-319, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 21 Sayı: 2
  • Basım Tarihi: 2016
  • Dergi Adı: JOURNAL OF BUON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.312-319
  • Anahtar Kelimeler: cancer, epithelial mesenchymal transition, stem cell, EGFR INHIBITOR RESISTANCE, CIRCULATING TUMOR-CELLS, BREAST-CANCER, PANCREATIC-CANCER, THERAPEUTIC TARGET, LUNG-CANCER, TRANSCRIPTIONAL REPRESSOR, DRUG-RESISTANCE, SELF-RENEWAL, METASTASIS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Purpose: Spread of cancer cells from the organ of the origin of them to another location, namely metastasis, is one of the most important factors that complicate the treatment of cancer. Therefore, research for the treatment of metastatic disease is gaining importance, especially for advanced cancers. This research focuses on the mechanisms that facilitate the metastatic tendency of cancer cells. Therefore, epithelial-mesenchymal transition (EMT) mechanism that helps the cells become metastatic and cancer stem cells (CSCs) present in the heterogeneous tumor mass are in the center of these researches.