Akademik Veri Yönetim Sistemi
İstanbul Journal of Pharmacy, cilt.55, sa.3, ss.1-9, 2025 (TRDizin)
In contemporary times, novel drug delivery systems play a crucial role in facilitating the effective and
safe transportation of drugs to their target sites, thus holding significant importance in research. Many
active pharmaceutical ingredients suffer from low oral bioavailability because of their poor solubility in
water and challenges in traversing biological membranes. To enhance therapeutic efficacy and mitigate
side effects in formulations of such drugs with low oral bioavailability, numerous drug delivery systems
have been developed. The most commonly elucidated systems are micelles, liposomes, dendrimers,
nanocapsules, and nanospheres. Lipid-based drug delivery systems are pivotal platforms that facilitate
the transport of drugs to target tissues, enhance solubility, and improve bioavailability. These systems
leverage the inherent properties of lipids to facilitate drug transport. Notably, cochleates are lipidic structures
that deserve particular attention within these systems. Cochleates are spiral structures formed as
a result of the interaction of calcium ions with negatively charged phospholipids. These lipidic structures
play a significant role in drug transport by protecting, stabilising, and facilitating the delivery of drugs to
the intended tissue.
This review discusses various aspects of cochleate, including their structure, formation, preparation,
utilisation as drug carriers, impact on bioavailability, and future potential. Additionally, the current status
and future prospects of cochleate will be evaluated.
This study provides a comprehensive overview of the advantages and potential applications of cochleate
in drug delivery.