Glutathione S-transferase P1 polymorphisms are associated with time to tumor progression in small cell lung cancer patients


Saip P. , Sen F., Vural B. , Ugurel E., Demirkan A., Derin D., ...Daha Fazla

JOURNAL OF BUON, cilt.16, ss.241-246, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 16 Konu: 2
  • Basım Tarihi: 2011
  • Dergi Adı: JOURNAL OF BUON
  • Sayfa Sayıları: ss.241-246

Özet

Purpose: Many of commonly used chemotherapeutics in lung cancer treatment are metabolized by glutathione-S transferases (GSTs). The placental isoform of GST (GSTP1) is the most abundant isoform in the lung. Polymorphisms within the GSTP1 may result in alterations in enzyme activity and change sensitivity to platinum-based chemotherapy. We investigated whether the polymorphism within the exons 5 and 6 of GSTP1 gene may change response to therapy, time to tumor progression (TTP) and overall survival in small cell lung cancer (SCLC) patients.