Glutathione S-transferase P1 polymorphisms are associated with time to tumor progression in small cell lung cancer patients


Saip P. , Sen F., Vural B. , Ugurel E., Demirkan A., Derin D., ...More

JOURNAL OF BUON, vol.16, no.2, pp.241-246, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 2
  • Publication Date: 2011
  • Title of Journal : JOURNAL OF BUON
  • Page Numbers: pp.241-246

Abstract

Purpose: Many of commonly used chemotherapeutics in lung cancer treatment are metabolized by glutathione-S transferases (GSTs). The placental isoform of GST (GSTP1) is the most abundant isoform in the lung. Polymorphisms within the GSTP1 may result in alterations in enzyme activity and change sensitivity to platinum-based chemotherapy. We investigated whether the polymorphism within the exons 5 and 6 of GSTP1 gene may change response to therapy, time to tumor progression (TTP) and overall survival in small cell lung cancer (SCLC) patients.